John Simes Selected Research

Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)

10/2018	Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.
11/2016	Interpretation of the evidence for the efficacy and safety of statin therapy.
10/2016	Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials.
5/2016	Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart Disease: Sixteen Years of Follow-Up of the LIPID Study.
4/2015	Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials.
1/2012	Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.
1/2010	A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.
7/2006	Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study.
12/2005	Effect of pravastatin in people with diabetes and chronic kidney disease.
9/2004	Effect of pravastatin on cardiovascular events in people with chronic kidney disease.

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John Simes Research Topics

Disease

24	Neoplasms (Cancer) 12/2022 - 12/2003
21	Myocardial Infarction 01/2022 - 01/2002
19	Coronary Disease (Coronary Heart Disease) 01/2022 - 04/2003
15	Stroke (Strokes) 10/2018 - 04/2003
14	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 07/2005
12	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 11/2011
12	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 09/2009
10	Acute Coronary Syndrome 01/2022 - 01/2002
6	Unstable Angina 01/2022 - 04/2003
5	Hypertension (High Blood Pressure) 01/2022 - 12/2009
5	Chronic Renal Insufficiency 01/2022 - 09/2004
5	Adenocarcinoma 05/2018 - 03/2007
5	Breast Neoplasms (Breast Cancer) 03/2016 - 01/2006
4	Nausea 12/2018 - 09/2006
4	Venous Thromboembolism 01/2018 - 11/2012
3	Vascular Diseases (Vascular Disease) 01/2018 - 11/2016
3	Heart Failure 12/2017 - 01/2009
3	Diabetes Mellitus 12/2017 - 11/2016
3	Disease Progression 11/2017 - 10/2016
3	Stomach Neoplasms (Stomach Cancer) 08/2017 - 07/2015
3	Type 2 Diabetes Mellitus (MODY) 11/2016 - 01/2009
3	Hemorrhage 09/2014 - 01/2002
2	Pancreatic Neoplasms (Pancreatic Cancer) 08/2021 - 05/2015
2	Carcinoma (Carcinomatosis) 01/2021 - 03/2007
2	Head and Neck Neoplasms (Head and Neck Cancer) 01/2021 - 01/2019
2	Vomiting 12/2018 - 06/2015
2	Fatigue 01/2018 - 09/2006
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2018 - 02/2004
2	Exanthema (Rash) 07/2014 - 09/2006
2	Diabetes Complications 03/2012 - 01/2009
1	Renal Insufficiency (Renal Failure) 05/2022
1	Cerebral Palsy (Spastic Diplegia) 01/2022
1	Deafness (Deaf Mutism) 01/2022
1	Sarcopenia 08/2021
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020
1	Rectal Neoplasms (Rectal Cancer) 01/2019
1	Squamous Cell Carcinoma of Head and Neck 01/2019

Drug/Important Bio-Agent (IBA)

20	Pravastatin (Pravachol)FDA LinkGeneric 01/2022 - 04/2003
19	LipidsIBA 01/2022 - 04/2003
10	Biomarkers (Surrogate Marker)IBA 12/2022 - 03/2014
10	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2018 - 09/2004
9	Cetuximab (Erbitux)FDA Link 01/2019 - 09/2009
8	Bevacizumab (Avastin)FDA Link 01/2022 - 06/2014
8	LDL CholesterolIBA 10/2018 - 05/2004
8	CholesterolIBA 03/2014 - 04/2003
5	ErbB Receptors (EGF Receptor)IBA 01/2019 - 09/2009
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2014
4	Temozolomide (Temodar)FDA LinkGeneric 10/2021 - 11/2011
4	Carboplatin (JM8)FDA LinkGeneric 12/2019 - 11/2015
3	fibrin fragment D (D-dimer)IBA 01/2019 - 12/2017
3	HDL CholesterolIBA 10/2018 - 05/2004
3	Troponin IIBA 01/2018 - 02/2014
3	Monoclonal AntibodiesIBA 01/2016 - 10/2010
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/2014 - 11/2012
3	Fenofibrate (CiL)FDA LinkGeneric 03/2012 - 01/2009
3	Pharmaceutical PreparationsIBA 04/2010 - 01/2002
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 12/2017
2	CreatinineIBA 01/2022 - 09/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 10/2016
2	Cystatin CIBA 01/2022 - 12/2017
2	Proteins (Proteins, Gene)FDA Link 12/2019 - 12/2015
2	depatuxizumab mafodotinIBA 01/2019 - 12/2017
2	Irinotecan (Camptosar)FDA LinkGeneric 12/2018 - 01/2016
2	Lipoprotein(a)IBA 10/2018 - 12/2013
2	regorafenibIBA 05/2018 - 10/2016
2	C-Reactive ProteinIBA 01/2018 - 12/2017
2	Epirubicin (Ellence)FDA LinkGeneric 08/2017 - 07/2015
2	Cisplatin (Platino)FDA LinkGeneric 08/2017 - 07/2015
2	Fluorouracil (Carac)FDA LinkGeneric 08/2017 - 07/2015
2	Epidermal Growth Factor (EGF)IBA 03/2016 - 12/2015
2	AnticoagulantsIBA 09/2014 - 11/2012
2	oxidized low density lipoproteinIBA 01/2012 - 05/2004
1	Capecitabine (Xeloda)FDA Link 01/2022
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2021
1	veliparibIBA 10/2021
1	MethyltransferasesIBA 10/2021
1	folfirinoxIBA 08/2021
1	mesoglycanIBA 01/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020
1	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2020
1	CeramidesIBA 01/2020
1	CannabinoidsIBA 12/2018
1	Dronabinol (THC)FDA LinkGeneric 12/2018
1	AntiemeticsIBA 12/2018

Therapy/Procedure

29	Therapeutics 12/2022 - 01/2002
18	Drug Therapy (Chemotherapy) 01/2022 - 09/2006
5	Radiotherapy 10/2021 - 01/2006
5	Secondary Prevention 12/2018 - 05/2004
4	Chemoradiotherapy 01/2021 - 03/2007
2	Immunotherapy 01/2022 - 01/2021
2	Combination Drug Therapy (Combination Chemotherapy) 07/2013 - 04/2009
2	Thrombolytic Therapy 02/2006 - 02/2004
2	Percutaneous Coronary Intervention 11/2005 - 01/2005
1	Peritoneal Dialysis 05/2022
1	Kidney Transplantation 05/2022
1	Cochlear Implants (Cochlear Implant) 01/2022
1	Hearing Aids (Hearing Aid) 01/2022
1	Molecular Targeted Therapy 01/2021
1	Laparotomy 01/2019